Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Oxidative Stress: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Oxidative Stress is a biological pathway involved in neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with ALS, Aging, Als. Connected to 2338 entities in the SciDEX knowledge graph.
| Name | Oxidative Stress |
| Key Genes/Proteins | PARKIN, PINK1, BDNF, TNF, NRF2, MTOR |
| Related Diseases | Aging, Inflammation |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
HSPA1A["HSPA1A"] -.->|"inhibits"| Oxidative_Stress["Oxidative Stress"]
ERK1["ERK1"] -->|"activates"| Oxidative_Stress["Oxidative Stress"]
HSPA1A_1["HSPA1A"] -->|"activates"| Oxidative_Stress["Oxidative Stress"]
HSP70["HSP70"] -->|"activates"| Oxidative_Stress["Oxidative Stress"]
style Oxidative_Stress fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | contributes_to | process | 0.95 |
| Neuronal Injury | causes | process | 0.95 |
| Apoptosis | causes | process | 0.95 |
| Alzheimer Disease | contributes_to | disease | 0.95 |
| Diabetes Mellitus | causes | disease | 0.95 |
| Spinal Cord Injury | involved_in | disease | 0.95 |
| Neurodegenerative Diseases | causes | disease | 0.95 |
| Tumor Cell Growth | regulates | phenotype | 0.95 |
| Tumor Microenvironment Remodeling | interacts_with | process | 0.95 |
| Diabetes Mellitus | contributes_to | disease | 0.95 |
| Diabetes Complications | contributes_to | disease | 0.95 |
| Redox Signaling | causes | pathway | 0.95 |
| Cancer | contributes_to | disease | 0.95 |
| Parkinson'S Disease | contributes_to | disease | 0.95 |
| Neurodegeneration | associated_with | process | 0.95 |
| ALZHEIMER'S DISEASE | causes | disease | 0.95 |
| Motor Neuron Death | causes | phenotype | 0.95 |
| Retinal Pigment Epithelium | causes | cell_type | 0.95 |
| Cancer | biomarker_for | disease | 0.92 |
| Apoptotic Pathways | activates | pathway | 0.92 |
| Mitochondrial Impairment | mediates | mechanism | 0.91 |
| Aging | contributes_to | disease | 0.90 |
| ASK1 | activates | protein | 0.90 |
| Mitochondrial Dysfunction | causes | phenotype | 0.90 |
| Autophagy | upregulates | process | 0.90 |
| Stress Granule Formation | causes | process | 0.90 |
| Neuronal Degeneration | contributes_to | process | 0.90 |
| Calcium Homeostasis | associated_with | process | 0.90 |
| CYSTEINE PROTEASES | modulates | enzyme | 0.90 |
| Parkinson's Disease | associated_with | disease | 0.90 |
| Age-Related Disorders | contributes_to | disease | 0.90 |
| Amyotrophic Lateral Sclerosis | contributes_to | disease | 0.90 |
| Neurotoxicity | causes | process | 0.90 |
| Mitochondrial Dysfunction | contributes_to | process | 0.90 |
| Oxidized Phosphatidylcholines | associated_with | compound | 0.90 |
| Intestinal Barrier Injury | causes | disease | 0.90 |
| Plasma Membrane Lysis | causes | process | 0.90 |
| Neurodegenerative Diseases | contributes_to | disease | 0.90 |
| Aging-Related Pathologies | contributes_to | disease | 0.90 |
| Stroke | contributes_to | disease | 0.90 |
| Stroke | involved_in | disease | 0.90 |
| Endothelial Dysfunction | contributes_to | disease | 0.90 |
| Cardiovascular Disease | contributes_to | disease | 0.90 |
| Insulin Production | inhibits | process | 0.90 |
| Lipid Peroxidation | causes | process | 0.90 |
| Inflammation | causes | process | 0.90 |
| Drug-Induced Retinal Toxicity | contributes_to | disease | 0.90 |
| Dopaminergic Neurons | causes | cell_type | 0.90 |
| Ferroptosis | causes | process | 0.90 |
| TDP-43 Aggregation | activates | process | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PARKIN | activates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| NRF2 | activates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| KEAP1 | regulates | gene | 1.00 |
| NRF2 | regulates | gene | 1.00 |
| KEAP1 | activates | gene | 1.00 |
| NRF2 | inhibits | gene | 1.00 |
| NRF2 | associated_with | gene | 1.00 |
| NLRP3 | activates | gene | 1.00 |
| Aging | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| Diabetes | regulates | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Neuroinflammation | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| Parkinson | therapeutic_target | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| P62 | activates | gene | 1.00 |
| Stroke | regulates | disease | 1.00 |
| Parkinson | regulates | disease | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Ischemia | inhibits | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| DNA | associated_with | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Cardiovascular | therapeutic_target | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Alzheimer | regulates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| Diabetes | activates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Stroke | therapeutic_target | disease | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||